Letter to editor: C‑reactive protein levels, the prognostic nutritional index, and the lactate dehydrogenase‑to‑lymphocyte ratio are important prognostic factors in primary central nervous system lymphoma: a single‑center study of 223 patients

Abstract

This critique evaluates a letter to the editor discussing prognostic factors in primary central nervous system lymphoma (PCNSL), focusing on C-reactive protein (CRP) levels, prognostic nutritional index (PNI), and lactate dehydrogenase (LDH)-to-lymphocyte ratio. While the letter provides valuable insights, limitations including reliance on a single-center dataset, lack of consideration for potential confounders, insufficient contextualization within existing literature, and limited discussion of clinical implications are identified. Addressing these limitations is crucial for enhancing the relevance and applicability of the findings in PCNSL management.

Keywords: C-reactive protein; CRP; LDH-to-lymphocyte ratio; Lactate dehydrogenase; PCNSL; PNI; Primary central nervous system lymphoma; Prognostic factors; Prognostic nutritional index.