The noncanonical NFκB pathway: Regulatory mechanisms in health and disease

Benancio N Rodriguez; Helen Huang; Jennifer J Chia; Alexander Hoffmann

doi:10.1002/wsbm.1646

The noncanonical NFκB pathway: Regulatory mechanisms in health and disease

WIREs Mech Dis. 2024 Apr 18:e1646. doi: 10.1002/wsbm.1646. Online ahead of print.

Authors

Benancio N Rodriguez^{1

2}, Helen Huang^{1

3}, Jennifer J Chia^{1

2

4}, Alexander Hoffmann^{1

2

3}

Affiliations

¹ Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California, USA.
² Molecular Biology Institute, University of California, Los Angeles, California, USA.
³ Institute for Quantitative and Computational Biosciences, University of California, Los Angeles, California, USA.
⁴ Department of Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA.

PMID: 38634218
DOI: 10.1002/wsbm.1646

Abstract

The noncanonical NFκB signaling pathway mediates the biological functions of diverse cell survival, growth, maturation, and differentiation factors that are important for the development and maintenance of hematopoietic cells and immune organs. Its dysregulation is associated with a number of immune pathologies and malignancies. Originally described as the signaling pathway that controls the NFκB family member RelB, we now know that noncanonical signaling also controls NFκB RelA and cRel. Here, we aim to clarify our understanding of the molecular network that mediates noncanonical NFκB signaling and review the human diseases that result from a deficient or hyper-active noncanonical NFκB pathway. It turns out that dysregulation of RelA and cRel, not RelB, is often implicated in mediating the resulting pathology. This article is categorized under: Immune System Diseases > Molecular and Cellular Physiology Cancer > Molecular and Cellular Physiology Immune System Diseases > Stem Cells and Development.

Keywords: NFκB; RelB; immune disorders; inflammatory disease; lymphoid cancers.

Publication types

Review

Abstract

Publication types

Grants and funding