Shining light on DHX9: UV-induced stress granules illuminate protective mechanisms for daughter cell resilience

Dylan M Parker; Gaia R Bublitz; Roy Parker

doi:10.1016/j.molcel.2024.03.027

Shining light on DHX9: UV-induced stress granules illuminate protective mechanisms for daughter cell resilience

Mol Cell. 2024 Apr 18;84(8):1403-1405. doi: 10.1016/j.molcel.2024.03.027.

Authors

Dylan M Parker¹, Gaia R Bublitz², Roy Parker³

Affiliations

¹ Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80309, USA; Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO 80309, USA.
² Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80309, USA.
³ Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80309, USA; Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO 80309, USA. Electronic address: roy.parker@colorado.edu.

PMID: 38640893
DOI: 10.1016/j.molcel.2024.03.027

Abstract

In a recent article in Cell, Zhou et al. investigate the origins, composition, and biological consequences of UV-induced stress granules. They find that UV-induced stress granules are triggered by the formation of RNA-protein crosslinks, uniquely contain DHX9 as a marker, form during mitosis independently of translation repression, and are enriched in intron-containing RNAs and splicing factors. Moreover, UV-induced granules contain double-stranded RNA (dsRNA) and trigger a dsRNA response. This work identifies a mechanism for resolving UV-damaged RNA and broadens the types of cytosolic "stress granules" that form.

MeSH terms

Mitosis
RNA, Double-Stranded / genetics
RNA, Double-Stranded / metabolism
Stress Granules*

Substances

RNA, Double-Stranded