Electroceuticals: emerging applications beyond the nervous system and excitable tissues

Swarnalatha Balasubramanian; David A Weston; Michael Levin; Devon Charles Cardoso Davidian

doi:10.1016/j.tips.2024.03.001

Electroceuticals: emerging applications beyond the nervous system and excitable tissues

Trends Pharmacol Sci. 2024 May;45(5):391-394. doi: 10.1016/j.tips.2024.03.001. Epub 2024 Apr 18.

Authors

Swarnalatha Balasubramanian¹, David A Weston², Michael Levin³, Devon Charles Cardoso Davidian⁴

Affiliations

¹ Emerging Innovations Unit, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Boston, Massachusetts, USA.
² Emerging Innovations Unit, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
³ Allen Discovery Center, Tufts University, Medford, MA, USA; Wyss Institute, Harvard University, Boston, MA, USA.
⁴ Allen Discovery Center, Tufts University, Medford, MA, USA. Electronic address: devon.davidian@tufts.edu.

PMID: 38641490
DOI: 10.1016/j.tips.2024.03.001

Abstract

Electroceuticals have evolved beyond devices manipulating neuronal signaling for symptomatic treatment, becoming more precise and disease modulating and expanding beyond the nervous system. These advancements promise transformative applications in arthritis, cancer treatment, tissue regeneration, and more. Here, we discuss these recent advances and offer insights for future research.

Keywords: bioelectricity; bioelectronic medicine; electroceuticals; ion channels; membrane potential.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Animals
Arthritis / therapy
Electric Stimulation Therapy / methods
Humans
Neoplasms* / therapy