Bone Marrow Harvest: A White Paper of Best Practices by the NMDP Marrow Alliance

Mark A Murakami; Laura Connelly-Smith; Thomas Spitzer; Adetola A Kassim; Sam L Penza; Monzr M Al Malki; James Mason; Chelsa Tourville; Brandon Magliocco; Jacklyn Barten; Hope Guidry-Groves; Jamie Margolis; Steven M Devine; Wolfgang P Rennert; Heather E Stefanski

doi:10.1016/j.jtct.2024.04.010

Bone Marrow Harvest: A White Paper of Best Practices by the NMDP Marrow Alliance

Transplant Cell Ther. 2024 Apr 18:S2666-6367(24)00349-X. doi: 10.1016/j.jtct.2024.04.010. Online ahead of print.

Authors

Affiliations

¹ Dana-Farber Cancer Institute, Boston, Massachusetts.
² Division of Hematology, Department of Medicine, University of Washington and Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, Washington.
³ Department of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts.
⁴ Department of Hematology and Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee.
⁵ Division of Hematology, The Ohio State University James Comprehensive Cancer Center, Columbus, Ohio.
⁶ City of Hope National Medical Center, Duarte, California.
⁷ Scripps Clinic, La Jolla, California.
⁸ National Marrow Donor Program, Minneapolis, Minnesota.
⁹ National Marrow Donor Program, Minneapolis, Minnesota; Center for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis, Minnesota.
¹⁰ Blood and Marrow Collection Program, MedStar Georgetown University Hospital, Washington, District of Columbia.
¹¹ National Marrow Donor Program, Minneapolis, Minnesota; Center for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis, Minnesota. Electronic address: hstefans@nmdp.org.

PMID: 38642840
DOI: 10.1016/j.jtct.2024.04.010

Abstract

Data on recent bone marrow harvest (BMH) collections from the NMDP has shown that bone marrow (BM) quality has decreased based on total nucleated cell count in the product. To ensure that quality BM products are available to all recipients, the NMDP Marrow Alliance was formed in April 2021 to increase the capability of BM collection centers to safely deliver high-quality products consistently and to identify and disseminate guidelines for performing BMH. This white paper describes the best practices for BMH as defined by the NMDP Marrow Alliance.

Keywords: Allogeneic; Bone marrow; Donor; Harvest.

Publication types

Practice Guideline