Occurrence, predictors, and management of late vascular complications following extracorporeal membrane oxygenation

C Adam Banks; Juliet Blakeslee-Carter; Veronica Nkie; Emily L Spangler; Shasha A Still; Kyle W Eudailey; Samuel K McElwee; Margaret S Blood; Zdenek Novak; Adam W Beck

doi:10.1016/j.jvs.2024.04.041

Occurrence, predictors, and management of late vascular complications following extracorporeal membrane oxygenation

J Vasc Surg. 2024 Apr 22:S0741-5214(24)01064-4. doi: 10.1016/j.jvs.2024.04.041. Online ahead of print.

Affiliations

¹ Division of Vascular Surgery and Endovascular Therapy, University of Alabama at Birmingham, Birmingham, AL.
² Alabama College of Osteopathic Medicine, Dothan, AL.
³ Division of Cardiothoracic Surgery, University of Alabama at Birmingham, Birmingham, AL.
⁴ Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL.
⁵ Division of Vascular Surgery and Endovascular Therapy, University of Alabama at Birmingham, Birmingham, AL. Electronic address: awbeck@uabmc.edu.

PMID: 38657701
DOI: 10.1016/j.jvs.2024.04.041

Abstract

Objective: Vascular complications (VCs) associated with extracorporeal membrane oxygenation (ECMO) during index hospitalization are prevalent and associated with increased mortality. Few studies have evaluated late VCs following ECMO; this study aims to assess occurrence and management practices of late VCs following discharge.

Methods: A retrospective single-institution review was performed of all patients surviving initial hospitalization after being cannulated for central or peripheral veno-venous (VV) or veno-arterial (VA) ECMO between January 1, 2019, and December 31, 2020. Primary outcomes were to categorize and determine the rate of late VCs. Late VCs were defined as any cannulated vessel injury resulting from ECMO cannulation presenting after discharge from index hospitalization. Analysis was conducted by cannulated vessel and stratified by VV or VA ECMO configurations.

Results: A total of 229 patients were identified, of which 50.6% (n = 116) survived until discharge. Late VCs occurred in 7.8% of the surviving cohort (n = 9/116); with a median time until presentation of 150 days (interquartile range, 83-251 days). The most common late VC was infection (n = 5; 55.6%) followed by progression to limb-threatening ischemia (n = 4; 44.4%). Urgent procedures were required in 55.6% of patients (n = 5), whereas 44.4% (n = 4) were elective interventions. Interventions performed for management of late VCs included lower extremity arterial revascularization (n = 6; 66.7%), major (n = 1; 11.1%) or minor amputation (n = 1; 11.1%), and wound debridement (n = 1; 11.1%). The majority of patients presenting with late VCs had initially been cannulated for peripheral VA ECMO (n = 8; 88.9%), and one patient (11.1%) was cannulated for peripheral VV ECMO. VCs during index hospitalization were seen in 77.8% of patients (n = 7) returning with late VCs. Odds for late VCs were significantly increased in patients that had been cannulated for ECMO as part of extracorporeal cardiopulmonary resuscitation (odds ratio, 8.4; P = .016) and in cases where patients had experienced an index VC during index hospitalization (odds ratio, 19.3; P = .001).

Conclusions: Late vascular complications after peripheral ECMO cannulation are not rare, particularly after arterial cannulation. Patients should be followed closely early after surviving ECMO with wound evaluation and formal assessment of perfusion with ankle-branchial indices in the cannulated limb.

Keywords: Acute limb ischemia; Bypass; Chronic limb-threatening ischemia; ECMO; Pseudoaneurysm; Seroma.