A Body Shape Index as a Simple Anthropometric Marker of Abdominal Obesity and Risk of Cardiovascular Events

Masato Kajikawa; Tatsuya Maruhashi; Shinji Kishimoto; Takayuki Yamaji; Takahiro Harada; Yusuke Saito; Aya Mizobuchi; Shunsuke Tanigawa; Yukiko Nakano; Kazuaki Chayama; Chikara Goto; Farina Mohamad Yusoff; Ayumu Nakashima; Yukihito Higashi

doi:10.1210/clinem/dgae282

A Body Shape Index as a Simple Anthropometric Marker of Abdominal Obesity and Risk of Cardiovascular Events

J Clin Endocrinol Metab. 2024 Apr 25:dgae282. doi: 10.1210/clinem/dgae282. Online ahead of print.

Authors

Affiliations

¹ Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan.
² Department of Regenerative Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
³ Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.
⁴ Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University Hiroshima, Japan.
⁵ Department of Physical Therapy, Hiroshima International University, Hiroshima, Japan.
⁶ Department of Nephrology, Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan.

PMID: 38661044
DOI: 10.1210/clinem/dgae282

Abstract

Background: A Body Shape Index (ABSI) has been reported to have associations with cardiovascular risk factors. However, there is no information on the association between ABSI and incidence of cardiovascular events.

Methods: We investigated the associations between ABSI and first major cardiovascular events (death from cardiovascular disease, nonfatal acute coronary syndrome, and nonfatal stroke) in 1857 subjects from the database of Flow-Mediated Dilation Japan registry and from Hiroshima University Vascular Function registry.

Results: The areas under the curves of ABSI to predict the first major cardiovascular events were superior to BMI (men: P=0.032, women: P=0.015) and waist circumference in women (men: P=0.078, women: P=0.002). The subjects were divided into two groups based on the cutoff value of ABSI for predicting first major cardiovascular events: a low ABSI group (<0.0822 in men and <0.0814 in women) and a high ABSI group (≥0.0822 in men and ≥0.0814 in women). During a median follow-up period of 41.6 months, 56 subjects died (23 from cardiovascular causes), 16 had nonfatal acute coronary syndrome, and 14 had nonfatal stroke. The Kaplan-Meier curves for first major cardiovascular events were significantly different between the two groups (men, P<0.001; women, P<0.001). Multivariate analysis revealed that high ABSI remained an independent predictor of first major cardiovascular events (men: hazard ratio, 2.33; 95% CI, 1.07 to 5.06; P=0.033; women: hazard ratio, 8.33; 95% CI, 1.06 to 65.49; P=0.044).

Conclusions: High ABSI is independently associated with incidence of cardiovascular events. ABSI calculation should be performed for evaluation of risk of cardiovascular events.

Keywords: A Body Shape Index; Atherosclerosis; Cardiovascular events; Obesity.

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