The synergistic effect of curcumin and mitoquinol mesylate on cognitive impairment and the neuropathology of Alzheimer's disease

Yongli Xie; Xuexia Li; Qingqing Shi; Linfeng Le; Chao Wang; Hao Xu; Guoli Wu; Xiubo Du; Zetao Chen

doi:10.1016/j.brainres.2024.148959

The synergistic effect of curcumin and mitoquinol mesylate on cognitive impairment and the neuropathology of Alzheimer's disease

Brain Res. 2024 Apr 24:1837:148959. doi: 10.1016/j.brainres.2024.148959. Online ahead of print.

Authors

Yongli Xie¹, Xuexia Li², Qingqing Shi³, Linfeng Le¹, Chao Wang⁴, Hao Xu¹, Guoli Wu¹, Xiubo Du⁵, Zetao Chen⁶

Affiliations

¹ College of Life Sciences and Oceanography, Guangdong Provincial Key Laboratory for Plant Epigenetics, Shenzhen University, Shenzhen 518055, China.
² College of Life Sciences and Oceanography, Guangdong Provincial Key Laboratory for Plant Epigenetics, Shenzhen University, Shenzhen 518055, China; Tianjin Institute for Food Safety Inspection Technology, Tianjin 300308, China; Shenzhen Bay Laboratory, Shenzhen 518055, China.
³ Department of Psychiatry, Xijing Hospital, Air Force Medical University, Xi'an 710032, Shanxi, China.
⁴ Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China.
⁵ College of Life Sciences and Oceanography, Guangdong Provincial Key Laboratory for Plant Epigenetics, Shenzhen University, Shenzhen 518055, China; Shenzhen Bay Laboratory, Shenzhen 518055, China.
⁶ College of Life Sciences and Oceanography, Guangdong Provincial Key Laboratory for Plant Epigenetics, Shenzhen University, Shenzhen 518055, China; Shenzhen Bao'an Traditional Chinese Medicine Hospital Group, Shenzhen 518133, China. Electronic address: 2060251030@email.szu.edu.cn.

PMID: 38670478
DOI: 10.1016/j.brainres.2024.148959

Abstract

Given the complexity and heterogeneity of Alzheimer's disease (AD) pathology, targeted monotherapy drugs may not be effective. Therefore, synergistic combination therapy of curcumin and Mito Q was proposed and evaluated in a triple-transgenic AD model mice (3 × Tg-AD mice). The cognitive ability was assessed using behavioral tests and typical pathological changes were observed through Western blotting and histological analysis. The results demonstrated a significant enhancement in cognitive ability along with the mitigation of typical AD pathological features such as Aβ aggregation, tau phosphorylation, and synaptic damage. Notably, the combination therapy demonstrated superior efficacy over individual drugs alone. These findings provide valuable insights for optimizing the development of AD drugs.

Keywords: Alzheimer's Disease; Curcumin; Mito Q; Synergistic Effect.