The centrosome: a critical hub for cell cycle regulation

Yuki Yoshino; Zhenzhou Fang; Natsuko Chiba

doi:10.1016/j.tcb.2024.04.003

The centrosome: a critical hub for cell cycle regulation

Trends Cell Biol. 2024 Apr 25:S0962-8924(24)00072-2. doi: 10.1016/j.tcb.2024.04.003. Online ahead of print.

Authors

Yuki Yoshino¹, Zhenzhou Fang², Natsuko Chiba³

Affiliations

¹ Department of Cancer Biology, Institute of Aging, Development, and Cancer, Tohoku University, 4-1 Seiryomachi, Aoba-ku, Sendai 980-8575, Japan; Laboratory of Cancer Biology, Graduate School of Life Sciences, Tohoku University, 4-1 Seiryomachi, Aoba-ku, Sendai 980-8575, Japan; Department of Cancer Biology, Tohoku University Graduate School of Medicine, 4-1 Seiryomachi, Aoba-ku, Sendai 980-8575, Japan.
² Department of Cancer Biology, Institute of Aging, Development, and Cancer, Tohoku University, 4-1 Seiryomachi, Aoba-ku, Sendai 980-8575, Japan; Laboratory of Cancer Biology, Graduate School of Life Sciences, Tohoku University, 4-1 Seiryomachi, Aoba-ku, Sendai 980-8575, Japan.
³ Department of Cancer Biology, Institute of Aging, Development, and Cancer, Tohoku University, 4-1 Seiryomachi, Aoba-ku, Sendai 980-8575, Japan; Laboratory of Cancer Biology, Graduate School of Life Sciences, Tohoku University, 4-1 Seiryomachi, Aoba-ku, Sendai 980-8575, Japan; Department of Cancer Biology, Tohoku University Graduate School of Medicine, 4-1 Seiryomachi, Aoba-ku, Sendai 980-8575, Japan. Electronic address: natsuko.chiba.c7@tohoku.ac.jp.

PMID: 38670849
DOI: 10.1016/j.tcb.2024.04.003

Abstract

Cyclins and cyclin-dependent kinases (CDKs) localize to the centrosome, but their significance in the cell cycle is unclear. Recently, Roberts et al. revealed that centrosomal cyclin B-CDK is required for mitotic entry and phosphorylation of substrates. This suggests that the centrosome acts as a signaling hub controlling the cell cycle.

Keywords: cell cycle; centrosome; cyclin; cyclin-dependent kinase; spindle pole body.