Low Expression MCEMP1 Promoting Lung Adenocarcinoma Progression by and its Clinical Value

Liqun Ling; Tianqi Hu; Chenkang Zhou; Shuhui Chen; Lunan Chou; Yuxin Chen; Zhaoting Hu; Kate Huang; Jie Chen; Yumin Wang; Junjun Wang

doi:10.2174/0115680096292054240409070618

Low Expression MCEMP1 Promoting Lung Adenocarcinoma Progression by and its Clinical Value

Curr Cancer Drug Targets. 2024 Apr 26. doi: 10.2174/0115680096292054240409070618. Online ahead of print.

Authors

Liqun Ling¹, Tianqi Hu¹, Chenkang Zhou¹, Shuhui Chen¹, Lunan Chou¹, Yuxin Chen¹, Zhaoting Hu², Kate Huang³, Jie Chen⁴, Yumin Wang^{1

5}, Junjun Wang¹

Affiliations

¹ Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University; Wenzhou, 325000, China.
² First Affiliated Hospital of Wenzhou Medical University Department of Clinical Laboratory Wenzhou China.
³ Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China.
⁴ Department of ICU, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China.
⁵ Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, Wenzhou 325015, China.

PMID: 38676531
DOI: 10.2174/0115680096292054240409070618

Abstract

Background: Lung cancer is a highly prevalent tumor with a lack of biological markers that reflect its progression. Mast cell surface membrane protein 1 (MCEMP1, also known as C19ORF59) has not been reported in lung adenocarcinoma (LUAD).

Objective: We aimed to investigate the role of MCEMP1 in LUAD.

Methods: MCEMP1 expression in LUAD was analyzed using The Cancer Genome Atlas (TCGA) data, and conducted univariate and multivariate Cox regression analyses to evaluate the prognostic significance of MCEMP1 expression in TCGA. Tumor Immune Estimation Resource (TIMER) was used for examining the correlation between MCEMP1 expression and immune cell infiltration in LUAD. Furthermore, proliferation, migration, invasion, and colony-forming ability were investigated using LUAD cell lines.

Results: MCEMP1 had low expression in LUAD patient tissues and was correlated with lymph node metastasis, differentiation level, and tumor status. The Area under Curve (AUC) value of MCEMP1 for the Receiver Operating Characteristic (ROC) curve analysis was 0.984. The immune infiltration analysis revealed a correlation between MCEMP1 expression and the extent of macrophages and neutrophil infiltration in LUAD. Additionally, MCEMP1 has low expression in clinical samples, MCEMP1 overexpressed in LUAD cells substantially reduced cell growth, migration, and invasion of malignant cells.

Conclusion: Low expression MCEMP1 promotes LUAD progression, which provides new insights and a potential biological target for future LUAD therapies.

Keywords: LUAD; MCEMP1; TCGA.; TME; biological marker; immune infiltration.