Delayed Puberty Including Constitutional Delay: Differential and Outcome

Abstract

Constitutional delay of growth and puberty (CDGP) is the most common cause of delayed puberty in both male and female individuals. This article reviews the causes of delayed puberty focusing on CDGP, including new advances in the understanding of the genetics underpinning CDGP, a clinical approach to discriminating CDGP from other causes of delayed puberty, outcomes, as well as current and potential emerging management options.

Keywords: Constitutional delay of growth and puberty; Delayed puberty; Hypogonadism.