[Large number of immature granulocytes in ascites caused by granulocyte colony-stimulating factor after chemotherapy for ovarian cancer: report of a case]

X L Guo; J Lu; X Y Qiao; Y F Xi

doi:10.3760/cma.j.cn112151-20231027-00318

[Large number of immature granulocytes in ascites caused by granulocyte colony-stimulating factor after chemotherapy for ovarian cancer: report of a case]

Zhonghua Bing Li Xue Za Zhi. 2024 May 8;53(5):504-506. doi: 10.3760/cma.j.cn112151-20231027-00318.

[Article in Chinese]

Authors

X L Guo¹, J Lu¹, X Y Qiao², Y F Xi¹

Affiliations

¹ Department of Pathology, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan 030013, China.
² Department of Medicine, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan 030013, China.

PMID: 38678338
DOI: 10.3760/cma.j.cn112151-20231027-00318

Abstract

卵巢癌是女性生殖系统常见的恶性肿瘤，早期多无明显临床症状，大多数患者就诊时已是中晚期，出现腹腔内扩散，伴发腹腔积液。对于中晚期卵巢癌，化疗是治疗的重要手段，而患者化疗后常产生骨髓抑制，导致中性粒细胞减少，严重者可影响患者的治疗及生存。聚乙二醇化重组人粒细胞集落刺激因子（PEG-rhG-CSF）是目前较常用的动员剂，可促进静息期造血干细胞进入细胞周期而大量增殖，增加外周血粒细胞，保证患者下一周期化疗顺利进行。本文报道1例卵巢癌患者化疗后白细胞低下，使用PEG-rhG-CSF后患者腹腔积液中出现大量幼稚粒细胞，在不了解病史的情况下容易误诊为髓系肿瘤，该情况罕见。.

Publication types

Case Reports

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Ascites* / etiology
Ascites* / pathology
Female
Granulocyte Colony-Stimulating Factor*
Granulocytes
Humans
Middle Aged
Ovarian Neoplasms* / drug therapy
Ovarian Neoplasms* / pathology
Polyethylene Glycols*
Recombinant Proteins*

Substances

Granulocyte Colony-Stimulating Factor
Polyethylene Glycols
Recombinant Proteins