Discovery of PSMA in the prostate of the common marmoset (Callithrix jacchus)

Diane E Peters; Michael Brownlee; Donna Layne-Colon; Barbara S Slusher

doi:10.1002/pros.24722

Discovery of PSMA in the prostate of the common marmoset (Callithrix jacchus)

Prostate. 2024 Apr 28. doi: 10.1002/pros.24722. Online ahead of print.

Authors

Diane E Peters^{1

2

3}, Michael Brownlee^{1

2}, Donna Layne-Colon⁴, Barbara S Slusher^{1

3

5

6

7

8

9}

Affiliations

¹ Johns Hopkins Drug Discovery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
² Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
³ Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁴ Southwest National Primate Research Center, San Antonio, Texas, USA.
⁵ Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁶ Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁷ Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁸ Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁹ Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

PMID: 38678435
DOI: 10.1002/pros.24722

Abstract

Background: Prostate-specific membrane antigen (PSMA) is a biomarker and therapeutic target of high relevance in prostate cancer. Although upregulated PSMA expression is a well-documented feature of prostatic neoplasia in both humans and canids, to date humans are the only species known to express PSMA basally in the prostate. Thus, traditional laboratory animal species have limited utility for studying PSMA biology in the prostate or for predicting efficacy or toxicity of PSMA-targeted agents.

Methods: PSMA expression in human, macaque, and marmoset prostates was determined by immunohistochemistry, employing an antibody with validated cross-species reactivity in a PSMA-positive control tissue; kidney.

Results: We newly discover that the common marmoset endogenously expresses PSMA in non-diseased prostate, similar to humans, and thus may be a valuable preclinical model for researchers studying PSMA.

Keywords: preclinical models; prostate; prostate specific membrane antigen.

Grants and funding

NH/NIH HHS/United States