The role of oxidative stress biomarkers in the development of peri-implant disease: A systematic review and meta-analysis

Jiaying Wang; Chaoming Hu; Xinyi Ma; Yichi Zhang; Xuejia Zhang; Xinhua Hong; Liang Chen; Yilin Wang; Jun Wang; Shuomin Chen; Qinhui Zhang; Yutian Wu; Menghan Wu; Yuge Chen; Zhongchen Song; Xiaoyu Sun; Shufan Zhao; Shengbin Huang

doi:10.1016/j.jdent.2024.105026

The role of oxidative stress biomarkers in the development of peri-implant disease: A systematic review and meta-analysis

J Dent. 2024 Apr 26:146:105026. doi: 10.1016/j.jdent.2024.105026. Online ahead of print.

Authors

Jiaying Wang¹, Chaoming Hu¹, Xinyi Ma¹, Yichi Zhang¹, Xuejia Zhang², Xinhua Hong¹, Liang Chen¹, Yilin Wang¹, Jun Wang¹, Shuomin Chen¹, Qinhui Zhang¹, Yutian Wu¹, Menghan Wu¹, Yuge Chen², Zhongchen Song³, Xiaoyu Sun⁴, Shufan Zhao⁵, Shengbin Huang⁶

Affiliations

¹ Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China; Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
² Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China; School of Dentistry, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.
³ Department of Periodontology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; College of Stomatology, Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, China.
⁴ Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China; Department of Periodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China. Electronic address: sunxyu@wmu.edu.cn.
⁵ Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China; Department of Oral and Maxillofacial Surgery, School of Stomatology, Wenzhou Medical University, Wenzhou, China. Electronic address: sf.zhao@wmu.edu.cn.
⁶ Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China; Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China. Electronic address: huangsb003@wmu.edu.cn.

PMID: 38679134
DOI: 10.1016/j.jdent.2024.105026

Abstract

Objectives: To analyze the role of oxidative stress (OS) biomarkers in peri‑implant diseases using a systematic review and meta-analysis approach. DATE: The review incorporated cross-sectional studies, randomized controlled trials, and case-control trials to evaluate the differences in OS biomarkers of peri‑implant disease.

Sources: A comprehensive literature search was conducted in electronic databases such as PubMed, Scopus, Embase, Web of Science, and CNKI, and no restrictions were applied during the search process.

Study selection: A total of 452 studies were identified, of which 18 were eligible for inclusion. Risk of bias and sensitivity analysis were assessed using Egger's test and funnel plots.

Results: We found that the levels of glutathione peroxidase (GSH-Px) in the peri‑implant sulcus fluid (PISF) of patients with peri‑implant diseases were significantly reduced (SMD = -1.40; 95 % CI = 1.70, -1.11; p < 0.001), while the levels of total myeloperoxidase (MPO) and malondialdehyde (MDA) were significantly increased (SMD = 0.46; 95 % CI = 0.12, 0.80; p = 0.008; SMD = 0.28; 95 % CI = 0.01, 0.56; p = 0.043). However, there were no significant differences of MPO concentration (SMD = 0.38; 95 % CI = -0.39, 1.15; p = 0.331) and superoxide dismutase (SOD)(SMD = -0.43; 95 % CI = -1.94, 1.07; p = 0.572) in PISF between peri‑implant disease group and control group. Similarly, salivary MPO did not show significant differences (SMD = 1.62; 95 % CI = -1.01, 4.24; p = 0.227).

Conclusions: Our results supported that the level of local OS biomarkers was closely related to peri‑implant diseases. GSH-Px, total MPO and MDA may be PISF biomarkers with good capability to monitor the development of peri‑implant disease.

Clinical significance: This study found significant differences in the levels of local OS biomarkers (GSH-Px, total MPO, and MDA) between patients with peri‑implant diseases and healthy subjects, which may be ideal candidate biomarkers for predicting and diagnosing peri‑implant diseases.

Keywords: Biomarker; Oxidative stress; Peri-implant disease; Peri-implant sulcular fluid; Peri-implantation mucosa; Saliva.

Publication types

Review