Sex-Based Disparities in the Transition to Dolutegravir-Based Antiretroviral Therapy in West African HIV Cohorts

Open Forum Infect Dis. 2024 Mar 19;11(5):ofae139. doi: 10.1093/ofid/ofae139. eCollection 2024 May.

Abstract

Transition to dolutegravir among 21 167 individuals experienced in antiretroviral therapy in West Africa showed heterogeneous timelines and patterns. Initially reported sex disparities tended to catch up over time with persisting disparities, according to contributing HIV clinics. Key factors facilitating dolutegravir switch were male sex, age <50 years, viral suppression, and regimens not based on protease inhibitors.

Keywords: HIV; West Africa; dolutegravir; sex disparities; switch.