New Indole Alkaloids from the Fungus Talaromyces assiutensis JTY2

Hong-Quan Zhu; Shuo Feng; Rong-Kun Xie; Zheng-Tian Zhu; Yong-Hao Lou; Xue-Ming Zhou; Xin-Ming Song

doi:10.1002/cbdv.202400937

New Indole Alkaloids from the Fungus Talaromyces assiutensis JTY2

Chem Biodivers. 2024 Apr 29:e202400937. doi: 10.1002/cbdv.202400937. Online ahead of print.

Authors

Hong-Quan Zhu¹, Shuo Feng¹, Rong-Kun Xie¹, Zheng-Tian Zhu¹, Yong-Hao Lou¹, Xue-Ming Zhou², Xin-Ming Song¹

Affiliations

¹ Hainan Normal University, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan 571158, China, haikou, CHINA.
² Hainan Normal University, college of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571158, People's Republic of China, 571158, Haikou, CHINA.

PMID: 38682724
DOI: 10.1002/cbdv.202400937

Abstract

Three new indole alkaloids, named talatensindoids A-C (1-3), together with two known biogenetically related indole alkaloids tryptamine (4) and L-tryptophan (5) were isolated from the Talaromyces assiutensis JTY2 based on the guidance of OSMAC approach. The structures of these indole alkaloids were determined by comprehensive spectroscopic analyses. The absolute configuration of 3 was confirmed by X-ray crystallographic analysis. Compound 1 represent the rare example of a chlorine-substituted indole alkaloid from natural products. The inhibitory activity of compounds 1-5 against two phytopathogenic fungi and three phytopathogenic bacteria was evaluated. Compound 1 exhibited broad spectrum antibacterial activities.

Keywords: Talaromyces assiutensis JTY2; antibacterial; antifungal; indole alkaloids.