Microneedles have emerged as the new class of local drug delivery system that has broad potential for development. Considering that the microneedles can penetrate tissue barriers quickly, and provide localized and targeted drug delivery, their applications have gradually expanded to non-transdermal drug delivery recently, which are capable of providing rapid and effective treatment for injuries and diseases of organs or tissues. However, a literature search revealed that there is a lack of summaries of the latest developments in non-transdermal drug delivery research by using biomedical polymeric microneedles. The review first described the materials and fabrication methods for the polymeric microneedles, and then reviewed a representative application of microneedles for non-transdermal drug delivery, with the primary focus being on treating and repairing the tissues or organs such as oral cavity, ocular tissues, blood vessels and heart. At the end of the article, the opportunities and challenges associated with microneedles for non-transdermal drug delivery were discussed, along with its future development, in order to provide reference for researchers in the relevant field.
微针是一种具有广阔发展前景的新型局部给药系统，因具有能够迅速穿透组织屏障、实现局部定点和靶向给药等优点，其应用也逐步扩展到非透皮的给药领域，可以为组织或器官的疾病或损伤提供快速、有效的治疗手段。经过文献检索发现医用高分子微针在非透皮给药的最新应用进展还缺乏归纳和总结，本文首先阐述了相关微针的制备材料及制造技术，接着对微针在非透皮给药领域中的典型应用进行了综述，主要涉及口腔、眼部、血管和心脏等组织或器官疾病的治疗及修复，最后总结现阶段微针在非透皮给药中存在的问题，对其发展进行了展望，以供相关领域的研究者借鉴与参考。.
Keywords: Drug delivery; Microneedle; Non-transdermal.