The effect of indoor air filtration on biomarkers of inflammation and oxidative stress: a review and meta-analysis of randomized controlled trials

Jingyi Ren; Zhenao Zhang; Qiqi Cui; Hao Tian; Zihao Guo; Yadong Zhang; Fengge Chen; Yandong Deng; Yuxia Ma

doi:10.1007/s11356-024-33414-7

The effect of indoor air filtration on biomarkers of inflammation and oxidative stress: a review and meta-analysis of randomized controlled trials

Environ Sci Pollut Res Int. 2024 Apr 30. doi: 10.1007/s11356-024-33414-7. Online ahead of print.

Authors

Jingyi Ren^#¹, Zhenao Zhang^#¹, Qiqi Cui², Hao Tian¹, Zihao Guo³, Yadong Zhang¹, Fengge Chen⁴, Yandong Deng⁵, Yuxia Ma⁶

Affiliations

¹ Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Hebei Key Laboratory of Environment and Human Health, Shijiazhuang, 050017, China.
² Undergraduate of College of Basic Medicine, Hebei Medical University, Shijiazhuang, 050017, China.
³ Undergraduate of College of Public Health, Hebei Medical University, Shijiazhuang, 050017, China.
⁴ Shijiazhuang Center for Disease Control and Prevention, Shijiazhuang, 050017, China.
⁵ Department of Ultrasonic, the First Hospital of Hebei Medical University, Shijiazhuang, 050017, China.
⁶ Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Hebei Key Laboratory of Environment and Human Health, Shijiazhuang, 050017, China. mayuxia@hebmu.edu.cn.

^# Contributed equally.

PMID: 38687452
DOI: 10.1007/s11356-024-33414-7

Abstract

Improvement of indoor air quality is beneficial for human health. However, previous studies have not reached consistent conclusions regarding the effects of indoor air filtration on inflammation and oxidative stress. This study aims to determine the relationship between indoor air filtration and inflammation and oxidative stress biomarkers. We conducted an electronic search that evaluated the association of indoor air filtration with biomarkers of inflammation and oxidative stress in five databases (PubMed, Cochrane Library, EMBASE, Web of Science, and Scopus) from the beginning to April 23, 2023. Outcomes included the following markers: interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), malondialdehyde (MDA), 8-hydroxy-2deoxyguanosine (8-OHdG), and 8-iso-prostaglandinF2α (8-isoPGF2α). We extracted data from the included studies according to the system evaluation and the preferred reporting item for meta-analysis (PRISMA) guidelines and used the Cochrane risk of bias tool to assess bias risk. Our meta-analysis included 15 studies with 678 participants to assess the combined effect size. The meta-analysis demonstrated that indoor air filtration could have a marked reduction in IL-6 (SMD: -0.275, 95% CI: -0.545 to -0.005, p = 0.046) but had no significant effect on other markers of inflammation or oxidative stress. Subgroup analysis results demonstrated a significant reduction in 8-OHdG levels in the subgroup with < 1 day of duration (SMD: -0.916, 95% CI: -1.513 to -0.320; p = 0.003) and using filtrete air filter (SMD: -5.530, 95% CI: -5.962 to -5.099; p < 0.001). Our meta-analysis results depicted that indoor air filtration can significantly reduce levels of inflammation and oxidative stress markers. Considering the adverse effects of air pollution on human health, our study provides powerful evidence for applying indoor air filtration to heavy atmospheric pollution.

Keywords: Indoor air filtration; Inflammation; Meta-analysis; Oxidative stress; Randomized controlled trials; Review.

Publication types

Review

Grants and funding

No. 81874264/National Natural Science Foundation of China