Supplementation with NAD+ and its precursors: A rescue of female reproductive diseases

Abstract

Nicotinamide adenine dinucleotide (NAD⁺) is an essential coenzyme involved in many pathophysiological processes. Supplementation with NAD⁺ and its precursors has been demonstrated as an emerging therapeutic strategy for the diseases. NAD⁺ also plays an important role in the reproductive system. Here, we summarize the function of NAD⁺ in various reproductive diseases and review the application of NAD⁺ and its precursors in the preservation of reproductive capacity and the prevention of embryonic malformations. It is shown that NAD⁺ shows good promise as a therapeutic approach for saving reproductive capacity.

Keywords: Female reproduction; Gynecologic tumor; NAD+; NAD+ precursors; Nicotinamide adenine dinucleotide; Ovarian diseases.