PM2.5 regulates the progression of lung adenocarcinoma through the axis of HCG18, miR-195 and ATG14

Clin Exp Pharmacol Physiol. 2024 Jun;51(6):e13861. doi: 10.1111/1440-1681.13861.

Abstract

Relevant studies have indicated the association of HCG18 with tumour occurrence and progression. In this study, we observed that PM2.5 can enhance the growth of lung adenocarcinoma cells by modulating the expression of HCG18. Further investigations, including overexpression and knockout experiments, elucidated that HCG18 suppresses miR-195, which in turn upregulates the expression of ATG14, resulting in the upregulation of autophagy. Consequently, exposure to PM2.5 leads to elevated HCG18 expression in lung tissues, which in turn increases Atg14 expression and activates autophagy pathways through inhibition of miR-195, thereby contributing to oncogenesis.

Keywords: PM2.5; autophagy; lncRNA HCG18; lung adenocarcinoma; miR‐195.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • A549 Cells
  • Adaptor Proteins, Vesicular Transport
  • Adenocarcinoma of Lung* / genetics
  • Adenocarcinoma of Lung* / metabolism
  • Adenocarcinoma of Lung* / pathology
  • Autophagy* / genetics
  • Autophagy-Related Proteins* / genetics
  • Autophagy-Related Proteins* / metabolism
  • Cell Line, Tumor
  • Cell Proliferation / genetics
  • Disease Progression*
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Lung Neoplasms* / genetics
  • Lung Neoplasms* / metabolism
  • Lung Neoplasms* / pathology
  • MicroRNAs* / genetics
  • MicroRNAs* / metabolism
  • Particulate Matter* / adverse effects
  • Vesicular Transport Proteins / genetics
  • Vesicular Transport Proteins / metabolism

Substances

  • MicroRNAs
  • Autophagy-Related Proteins
  • MIRN195 microRNA, human
  • Particulate Matter
  • ATG14 protein, human
  • Vesicular Transport Proteins
  • Adaptor Proteins, Vesicular Transport