Multiple functions of HMGB1 in cancer

Guangyao Lv; Menglin Yang; Keke Gai; Qiong Jia; Zhenzhen Wang; Bin Wang; Xueying Li

doi:10.3389/fonc.2024.1384109

Multiple functions of HMGB1 in cancer

Front Oncol. 2024 Apr 25:14:1384109. doi: 10.3389/fonc.2024.1384109. eCollection 2024.

Authors

Guangyao Lv¹, Menglin Yang², Keke Gai¹, Qiong Jia¹, Zhenzhen Wang¹, Bin Wang¹, Xueying Li³

Affiliations

¹ Department of Pharmacy, Binzhou Medical University Hospital, Binzhou, Shandong, China.
² Quality Management Department, Marine Biomedical Research Institute of Qingdao, Qingdao, China.
³ School of Health, Binzhou Polytechnic, Binzhou, China.

Abstract

High mobility group box 1 (HMGB1) is a nuclear DNA-binding protein with a dual role in cancer, acting as an oncogene and a tumor suppressor. This protein regulates nucleosomal structure, DNA damage repair, and genomic stability within the cell, while also playing a role in immune cell functions. This review comprehensively evaluates the biological and clinical significance of HMGB1 in cancer, including its involvement in cell death and survival, its potential as a therapeutic target and cancer biomarker, and as a prosurvival signal for the remaining cells after exposure to cytotoxic anticancer treatments. We highlight the need for a better understanding of the cellular markers and mechanisms involved in the involvement of HMGB1in cancer, and aim to provide a deeper understanding of its role in cancer progression.

Keywords: HMGB1; autophagy; cancer; chemotherapy resistance; immunotherapy.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research was funded by “TCM science and technology project of Shandong Province, grant number Q-2023105” and “Science and Technology project of Binzhou medical university, grant number BY2021KJ44”.