Objective: Granulomatous invasive fungal sinusitis (GIFS) is a rare and life-threatening disease, whereas fungus ball (FB) is the most common form of noninvasive fungal sinusitis. Both GIFS and FB primarily develop in immunocompetent patients, with the former associated with higher mortality and morbidity.
Methods: A chart review and review of the literature.
Results: We present the case of a 77-year-old woman with mixed fungal sinusitis who was successfully treated with voriconazole.
Conclusions: GIFS and FB can coexist in extremely rare cases, known as mixed fungal sinusitis; however, the diagnosis and subsequent treatment of mixed fungal sinusitis can be delayed because of a lack of awareness of the underlying concept. Therefore, it is crucial for clinicians to recognize the concept of mixed fungal sinusitis.
Keywords: endoscopic sinus surgery; fungus ball; granulomatous invasive fungal sinusitis; pterygopalatine fossa; voriconazole.