Comparison of the use of a spiral nasojejunal tube and transendoscopic enteral tubing in washed microbiota transplantation via the mid-gut route

Ya-Mei Zheng; Hui-Yi Wu; Meng-Meng Ye; Jie-Yi Cai; Yu Yuan; Wen-Rui Xie; Jia-Ting Xu; Tao Liu; Xing-Xiang He; Li-Hao Wu

doi:10.1016/j.heliyon.2024.e30310

Comparison of the use of a spiral nasojejunal tube and transendoscopic enteral tubing in washed microbiota transplantation via the mid-gut route

Heliyon. 2024 Apr 30;10(9):e30310. doi: 10.1016/j.heliyon.2024.e30310. eCollection 2024 May 15.

Authors

Ya-Mei Zheng¹, Hui-Yi Wu¹, Meng-Meng Ye¹, Jie-Yi Cai¹, Yu Yuan¹, Wen-Rui Xie¹, Jia-Ting Xu¹, Tao Liu¹, Xing-Xiang He¹, Li-Hao Wu¹

Affiliation

¹ Department of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Research Center for Engineering Techniques of Microbiota-Targeted Therapies of Guangdong Province, Guangzhou, 510080, Guangdong Province, China.

Abstract

Background: Methods for washed microbiota transplantation (WMT) through the mid-gut include transendoscopic enteral tubing (TET) and manual spiral nasojejunal tube (SNT) placement have not been studied.

Methods: This prospective interventional study was performed at a single centre. Patients were divided into the SNT and mid-gut TET groups based on their conditions and wishes. In the SNT group, an SNT was passively inserted into the stomach, and abdominal X-rays were taken within 24 h to confirm tube placement in the small intestine. In the mid-gut TET group, mid-gut TET was placed in the small intestine for gastroscopy. Data on the clinical efficacy of WMT, intubation time, cost, overall comfort score, adverse reactions, etc., were collected from the two groups.

Results: Sixty-three patients were included in the study (SNT group (n = 40) and mid-gut TET group (n = 23)). The clinical efficacy of WMT in the SNT and mid-gut TET groups was 90 % and 95.7 %, respectively (P = 0.644). Compared with the mid-gut TET group, the SNT group showed a shorter operation time (120 s vs. 258 s, P = 0.001) and a lower average cost (641.7 yuan vs. 1702.1 yuan, P = 0.001). There was no significant difference in the overall comfort score or the incidence of common discomfort symptoms between the two groups.

Conclusion: The different implantation methods have different advantages; compared with mid-gut TET placement, manual SNT placement provides some benefits.

Keywords: Mid-gut route; Spiral nasojejunal tube; Transendoscopic enteral tubing; Washed microbiota transplantation.