Cevanine-type steroidal alkaloids from the bulbs of Fritillaria cirrhosa D. Don

Hui-Wen Dong; Shu-Hui Wang; Tse Wai Ming; Shao-Bing Fu; Yun-Hu Zhang; Jia-Wei Li; Qing-Ying Zhang; Peng-Fei Tu; Hong Liang

doi:10.1016/j.phytochem.2024.114140

Cevanine-type steroidal alkaloids from the bulbs of Fritillaria cirrhosa D. Don

Phytochemistry. 2024 May 13:224:114140. doi: 10.1016/j.phytochem.2024.114140. Online ahead of print.

Authors

Hui-Wen Dong¹, Shu-Hui Wang¹, Tse Wai Ming², Shao-Bing Fu², Yun-Hu Zhang¹, Jia-Wei Li¹, Qing-Ying Zhang¹, Peng-Fei Tu³, Hong Liang⁴

Affiliations

¹ State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, PR China.
² Nin Jiom Medicine Manufactory (H.K.) Limited, Hong Kong, 999077, PR China.
³ State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, PR China. Electronic address: pengfeitu@bjmu.edu.cn.
⁴ State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, PR China. Electronic address: lianghong@bjmu.edu.cn.

PMID: 38750709
DOI: 10.1016/j.phytochem.2024.114140

Abstract

Eight previously undescribed cevanine-type steroidal alkaloids, cirrhosinones I-N and cirrhosinols A-B, along with five known analogs, were isolated from the bulbs of Fritillaria cirrhosa D. Don. Their structures were elucidated on the basis of comprehensive analysis of HRESIMS, 1D and 2D NMR spectroscopic data, and single-crystal X-ray diffraction analyses. All compounds revealed weak NO inhibitory activities in the LPS-stimulated NR8383 cells at the concentration of 20 μM, with inhibition ratios ranging from 5.1% to 14.3%.

Keywords: Cevanine-type steroidal alkaloids; Fritillaria cirrhosan D. Don; Liliaceae.