Comprehensive variant analysis of phospholipase A2 superfamily genes in large Chinese Parkinson' s disease cohorts

Jiabin Liu; Yige Wang; Yuwen Zhao; Hongxu Pan; Zhenhua Liu; Qian Xu; Shen Lu; Hong Jiang; Junling Wang; Qiying Sun; Jieqiong Tan; Xinxiang Yan; Jinchen Li; Beisha Tang; Jifeng Guo

doi:10.1016/j.mad.2024.111940

Comprehensive variant analysis of phospholipase A2 superfamily genes in large Chinese Parkinson' s disease cohorts

Mech Ageing Dev. 2024 Jun:219:111940. doi: 10.1016/j.mad.2024.111940. Epub 2024 May 14.

Authors

Jiabin Liu¹, Yige Wang¹, Yuwen Zhao¹, Hongxu Pan¹, Zhenhua Liu², Qian Xu¹, Shen Lu¹, Hong Jiang¹, Junling Wang¹, Qiying Sun³, Jieqiong Tan⁴, Xinxiang Yan¹, Jinchen Li⁵, Beisha Tang², Jifeng Guo⁶

Affiliations

¹ Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
² Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, China; Centre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
³ Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁴ Centre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
⁵ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Centre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China; Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁶ Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, China; Centre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China; Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, China. Electronic address: guojifeng@csu.edu.cn.

PMID: 38750970
DOI: 10.1016/j.mad.2024.111940

Abstract

To clarify the genetic role of phospholipase A2 (PLA2) genes in Parkinson's disease (PD), we performed a genetic association study in large Chinese population cohorts using next-generation sequencing. In this study, we analyzed both rare and common variants of 38 phospholipase A2 genes in two large cohorts. We detected 1558 and 1115 rare variants in these two cohorts, respectively. In both cohorts, we observed suggestive associations between specific subgroups and the risk of PD. At the single-gene level, several genes (PLA2G2D, PLA2G12A, PLA2G12B, PLA2G4F, PNPLA1, PNPLA3, PNPLA7, PLA2G7, PLA2G15, PLAAT5, and ABHD12) are suggestively associated with PD. Meanwhile, 364 and 2261 common variants were identified in two cohorts, respectively. Our study has expanded the genetic spectrum of the PLA2 family genes and suggested potential pathogenetic roles of PLA2 superfamily in PD.

Keywords: Burden analysis; Common variants; Parkinson’s disease; Phospholipase A2; Rare variants.

MeSH terms

Aged
Asian People / genetics
China / epidemiology
Cohort Studies
East Asian People
Female
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Parkinson Disease* / genetics
Phospholipases A2* / genetics

Substances

Phospholipases A2