Response to gallamine: an indicator of diminished neuromuscular function in experimental autoimmune myasthenia gravis

J Neurosci Res. 1985;14(2):271-8. doi: 10.1002/jnr.490140212.

Abstract

A test for diminished neuromuscular function in animals with experimental autoimmune myasthenia gravis is described. Within minutes following an injection of gallamine triethiodide, mice exhibit a dramatic yet transient response which is dose-dependent. Mice previously inoculated with acetylcholine receptor are approximately twice as sensitive to gallamine as normal mice. Positive results have been found in over 80% of receptor-inoculated BALB/c mice and in 94% of C57Bl/6 mice.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Autoantibodies / biosynthesis
  • Autoimmune Diseases / physiopathology*
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Electrophysiology
  • Exercise Test
  • Gallamine Triethiodide*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Motor Neurons / physiology
  • Myasthenia Gravis / physiopathology*
  • Reaction Time
  • Receptors, Cholinergic / administration & dosage
  • Receptors, Cholinergic / immunology
  • Receptors, Cholinergic / physiology*

Substances

  • Autoantibodies
  • Receptors, Cholinergic
  • Gallamine Triethiodide