Abstract
A test for diminished neuromuscular function in animals with experimental autoimmune myasthenia gravis is described. Within minutes following an injection of gallamine triethiodide, mice exhibit a dramatic yet transient response which is dose-dependent. Mice previously inoculated with acetylcholine receptor are approximately twice as sensitive to gallamine as normal mice. Positive results have been found in over 80% of receptor-inoculated BALB/c mice and in 94% of C57Bl/6 mice.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Autoantibodies / biosynthesis
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Autoimmune Diseases / physiopathology*
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Electrophysiology
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Exercise Test
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Gallamine Triethiodide*
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Motor Neurons / physiology
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Myasthenia Gravis / physiopathology*
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Reaction Time
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Receptors, Cholinergic / administration & dosage
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Receptors, Cholinergic / immunology
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Receptors, Cholinergic / physiology*
Substances
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Autoantibodies
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Receptors, Cholinergic
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Gallamine Triethiodide