Increases in alpha-adrenergic receptors in the hypothalamus of the genetically obese mouse (ob/ob)

Brain Res. 1981 Oct 19;222(2):411-6. doi: 10.1016/0006-8993(81)91046-5.

Abstract

Despite significantly elevated hypothalamic norepinephrine levels, genetically obese mice (ob/ob) had more hypothalamic alpha-adrenergic receptors than their lean littermates. This receptor increase appeared to be specific to the alpha-receptors in the hypothalamus since no change was found in the number of alpha-receptors in the cortex or in the dopamine and muscarinic receptors in the cortex and striatum.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adrenergic alpha-Antagonists / metabolism
  • Animals
  • Cerebral Cortex / metabolism
  • Corpus Striatum / metabolism
  • Dioxanes / metabolism
  • Female
  • Hypothalamus / metabolism*
  • Kinetics
  • Mice
  • Mice, Obese
  • Organ Specificity
  • Receptors, Adrenergic / metabolism*
  • Receptors, Adrenergic, alpha / metabolism*

Substances

  • Adrenergic alpha-Antagonists
  • Dioxanes
  • Receptors, Adrenergic
  • Receptors, Adrenergic, alpha
  • (2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane