Functional significance of idiopathic adrenal calcification in the adult

Clin Endocrinol (Oxf). 1980 Apr;12(4):319-25. doi: 10.1111/j.1365-2265.1980.tb02717.x.

Abstract

Two young adults with idiopathic adrenal calcification are described. In one patient the calcification was probably secondary to adrenal haemorrhage in the neonatal period. Neither patient exhibited clinical features suggestive of adrenal cortical insufficiency, and baseline serum cortisol levels were normal. The corticosteroid responses to ACTH administration and to other provocative tests indicated that both glucocorticoid and mineralocorticoid reserve was normal. One patient showed an appropriate epinephrine response to insulin-induced hypoglycaemia. We conclude that even extensive adrenal calcification may be compatible with completely normal adrenal function. Since, however, little is known of the natural history of this condition, lifelong follow-up of such patients is advised.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adrenal Cortex Function Tests
  • Adrenal Gland Diseases / physiopathology*
  • Adrenocorticotropic Hormone
  • Adult
  • Calcinosis / physiopathology*
  • Humans
  • Insulin
  • Male

Substances

  • Insulin
  • Adrenocorticotropic Hormone