Efficacy of aztreonam in treatment of experimental syphilis in rabbits

S A Lukehart; S A Baker-Zander; K K Holmes

doi:10.1128/AAC.25.3.390

Efficacy of aztreonam in treatment of experimental syphilis in rabbits

Antimicrob Agents Chemother. 1984 Mar;25(3):390-1. doi: 10.1128/AAC.25.3.390.

Authors

S A Lukehart, S A Baker-Zander, K K Holmes

Abstract

The efficacy of aztreonam (SQ 26,776) in the therapy of active syphilis infection was evaluated in the rabbit model. Aztreonam was effective in treating active syphilis at a dose of 25 mg/kg given intramuscularly twice daily for 10 days; doses of 2.5 and 0.25 mg/kg were not effective.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Bacterial Agents / therapeutic use*
Aztreonam
Male
Penicillin G Benzathine / pharmacology
Rabbits
Syphilis / drug therapy*
Syphilis / microbiology
Treponema pallidum

Substances

Anti-Bacterial Agents
Aztreonam
Penicillin G Benzathine