The possible role of ATP-dependent proteolysis on the solubilization of methemoglobin reductase during reticulocyte maturation

Biochem Biophys Res Commun. 1983 Oct 31;116(2):357-9. doi: 10.1016/0006-291x(83)90529-6.

Abstract

The ATP-dependent proteolytic system present in reticulocytes can release the active hydrophilic domain of cytochrome b5 and NADH-cytochrome b5 reductase from the endoplasmic reticulum, that in mature erythrocytes act as methemoglobin reductase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / metabolism*
  • Animals
  • Cytochrome Reductases / metabolism
  • Cytochrome b Group / metabolism
  • Cytochrome-B(5) Reductase / metabolism*
  • Cytochromes b5
  • NADH, NADPH Oxidoreductases / metabolism*
  • Rabbits
  • Rats
  • Reticulocytes / enzymology*
  • Solubility

Substances

  • Cytochrome b Group
  • Adenosine Triphosphate
  • Cytochromes b5
  • NADH, NADPH Oxidoreductases
  • Cytochrome Reductases
  • Cytochrome-B(5) Reductase