Abstract
Sister-chromatid exchange and chromosomal aberrations were measured in vivo in mouse bone marrow following intraperitoneal injection of the cooked food mutagens, Trp-P-2 and IQ. Trp-P-2 produced a significant positive dose response for both endpoints while IQ produced only a weak but significant sister-chromatid exchange response. The relative potency of these two chemicals is similar to that seen in mammalian cells in vitro but opposite to their potency in Salmonella.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Bone Marrow / drug effects*
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Carbolines / toxicity*
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Chromosome Aberrations*
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Crossing Over, Genetic / drug effects*
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Cyclophosphamide / toxicity
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Food
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Hot Temperature
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Indoles / toxicity*
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Male
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Mice
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Mice, Inbred C57BL
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Mutagenicity Tests
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Mutagens / toxicity*
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Mutation*
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Quinolines / toxicity*
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Sister Chromatid Exchange / drug effects*
Substances
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Carbolines
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Indoles
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Mutagens
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Quinolines
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2-amino-3-methylimidazo(4,5-f)quinoline
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3-amino-1-methyl-5H-pyrido(4,3-b)indole
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Cyclophosphamide