In vivo cytogenetic effects of the cooked-food-related mutagens Trp-P-2 and IQ in mouse bone marrow

Mutat Res. 1984 Jun-Jul;140(2-3):49-53. doi: 10.1016/0165-7992(84)90041-1.

Abstract

Sister-chromatid exchange and chromosomal aberrations were measured in vivo in mouse bone marrow following intraperitoneal injection of the cooked food mutagens, Trp-P-2 and IQ. Trp-P-2 produced a significant positive dose response for both endpoints while IQ produced only a weak but significant sister-chromatid exchange response. The relative potency of these two chemicals is similar to that seen in mammalian cells in vitro but opposite to their potency in Salmonella.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Bone Marrow / drug effects*
  • Carbolines / toxicity*
  • Chromosome Aberrations*
  • Crossing Over, Genetic / drug effects*
  • Cyclophosphamide / toxicity
  • Food
  • Hot Temperature
  • Indoles / toxicity*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mutagenicity Tests
  • Mutagens / toxicity*
  • Mutation*
  • Quinolines / toxicity*
  • Sister Chromatid Exchange / drug effects*

Substances

  • Carbolines
  • Indoles
  • Mutagens
  • Quinolines
  • 2-amino-3-methylimidazo(4,5-f)quinoline
  • 3-amino-1-methyl-5H-pyrido(4,3-b)indole
  • Cyclophosphamide