Abstract
The cytogenetic effects of homo-aza-steroidal ester (ASE) on Chinese hamster ovary (CHO) cells in vitro are reported. It was found that treatment of cells with a dose as low as 0.025 micrograms/ml of ASE causes a significant number of abnormal metaphases containing mostly chromatid-type aberrations. Similarly, significant frequencies of SCE were induced with only 0.075 micrograms/ml of ASE.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antineoplastic Agents / toxicity*
-
Azasteroids*
-
Cell Line
-
Chromosome Aberrations*
-
Chromosome Disorders*
-
Cricetinae
-
Cricetulus
-
Crossing Over, Genetic / drug effects*
-
Female
-
Mutagenicity Tests
-
Mutagens*
-
Nitrogen Mustard Compounds / toxicity*
-
Ovary
-
Sister Chromatid Exchange / drug effects*
Substances
-
Antineoplastic Agents
-
Azasteroids
-
Mutagens
-
Nitrogen Mustard Compounds
-
3-(((4-(bis(2-chloroethyl)amino)phenyl)acetyl)oxy)-17a-aza-D-homoandrost-5-en-17-one