Abstract
Idiotype-positive molecules induced by xenogeneic anti-idiotypes (anti-Id) to monoclonal anti-H-2 antibodies were studied using syngeneic anti-Id reagents. Syngeneic reagents detected idiotypes on both H-2 antigen-binding and nonbinding Id' induced by xenogeneic anti-Id. In addition, idiotopes were readily detected by alloimmunization after xenogeneic anti-Id reagents interact with some of the same antibodies as syngeneic anti-Id and support the hypothesis that treatment with xenogeneic anti-Id may affect a physiologically important idiotypic network.
MeSH terms
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Animals
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Antibodies, Anti-Idiotypic / administration & dosage*
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Antibodies, Anti-Idiotypic / biosynthesis
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Antibodies, Anti-Idiotypic / genetics
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Antibodies, Monoclonal / analysis
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Antibodies, Monoclonal / genetics
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Antibodies, Monoclonal / immunology
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Binding Sites, Antibody
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Immunoglobulin Idiotypes / analysis
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Immunoglobulin Idiotypes / genetics
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Immunoglobulin Idiotypes / immunology*
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Isoantibodies / analysis*
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Isoantibodies / genetics
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Isoantibodies / immunology
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Mice
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Mice, Inbred A
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Mice, Inbred BALB C
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Rabbits
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Swine
Substances
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Antibodies, Anti-Idiotypic
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Antibodies, Monoclonal
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Immunoglobulin Idiotypes
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Isoantibodies
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anti-H-2 antibodies