Intermittent pain and hyperthermia were the major signs in a ten-year-old male Kerry Blue terrier. Extensive radiologic examination of the skeleton revealed no abnormalities. Gamma camera imaging of the skeleton revealed multiple foci of increased uptake of a bone-seeking radiopharmaceutical. Histologic examination of a bone biopsy provided a tentative diagnosis of osteomyelitis. Therapy with antibiotics was not successful. At autopsy, anaplastic carcinoma was found in the liver, spleen, several lymph nodes, ribs, both humeri, both femurs and almost all vertebrae.