Megavitamins for minimal brain dysfunction. A placebo-controlled study

JAMA. 1978 Dec 8;240(24):2642-3.

Abstract

Preliminary to a stimulant comparison study, 31 children with minimal brain dysfunction randomly received either placebo or a megavitamin combination. During a two-week trial, only two children responded so well that stiumlants were not considered necessary; both were in the placebo group. Change scores from pretest to posttest on four blind ratings by teachers and parents did not show a significant difference between the placebo and vitamin groups.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Ascorbic Acid / therapeutic use
  • Attention Deficit Disorder with Hyperactivity / drug therapy*
  • Child
  • Female
  • Glutamates / therapeutic use
  • Humans
  • Hyperkinesis / drug therapy
  • Learning Disabilities / drug therapy
  • Male
  • Nicotinic Acids / therapeutic use
  • Orthomolecular Therapy* / methods
  • Pantothenic Acid / therapeutic use
  • Pyridoxine / therapeutic use

Substances

  • Glutamates
  • Nicotinic Acids
  • Pantothenic Acid
  • Pyridoxine
  • Ascorbic Acid