Metabolism of limonene-1,2-epoxide in the rat

Xenobiotica. 1980 Dec;10(12):859-61. doi: 10.3109/00498258009033819.

Abstract

1. The metabolism of limonene-1,2-epoxide was studied following intraperitoneal injection in rats and in rat liver homogenates. 2. Limonene-1,2-glycol was the only neutral metabolite detected. Major limonene metabolites, p-mentha-2,8-dien-1-alpha and -beta-ol and p-mentha-1,8-dien-6-alpha and -beta-ol were not observed. 3. Limonene-1,2-epoxide is not a major intermediate in limonene metabolism in the rat.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cyclohexane Monoterpenes
  • In Vitro Techniques
  • Liver / metabolism*
  • Male
  • Microsomes, Liver / metabolism
  • Monoterpenes*
  • Rats
  • Terpenes / metabolism*

Substances

  • Cyclohexane Monoterpenes
  • Monoterpenes
  • Terpenes
  • limonene-1,2-epoxide