Active myocardial damage in hyperthyroidism. A concurrent mechanism of heart failure reversed by treatment

Eur Heart J. 1995 Jul;16(7):1014-6. doi: 10.1093/oxfordjournals.eurheartj.a061014.

Abstract

A patient with hyperthyroidism, heart failure, and depressed ejection fraction, in whom myocardial damage was evidenced by In111-labelled monoclonal antimyosin antibodies, is presented. Both myocardial damage and left ventricular dysfunction disappeared after antithyroid therapy. This suggests that, in addition to volume overload, heart failure in hyperthyroidism could be also due to the presence of potentially reversible concurrent myocardial damage.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies, Monoclonal*
  • Antithyroid Agents / therapeutic use*
  • Carbimazole / therapeutic use*
  • Cardiomyopathies / diagnostic imaging*
  • Cardiomyopathies / drug therapy
  • Follow-Up Studies
  • Heart Failure / diagnostic imaging*
  • Heart Failure / drug therapy
  • Hemodynamics / drug effects
  • Hemodynamics / physiology
  • Humans
  • Hyperthyroidism / diagnostic imaging*
  • Hyperthyroidism / drug therapy
  • Indium Radioisotopes / therapeutic use
  • Male
  • Myosins / immunology*
  • Radionuclide Imaging
  • Ventricular Function, Left / drug effects
  • Ventricular Function, Left / physiology

Substances

  • Antibodies, Monoclonal
  • Antithyroid Agents
  • Indium Radioisotopes
  • Carbimazole
  • Myosins