Abstract
Cloning and sequence analysis of cDNA showed that the brain type of ryanodine receptor (RYR) is expressed in human Jurkat T-lymphocyte cells. Fura-2 measurements revealed that the RYR in T-cells functions as a ryanodine-sensitive, caffeine-insensitive Ca2+ release channel. Furthermore, ryanodine stimulated proliferation and altered the growth pattern of cultured human T-cells when added together with FK506.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Base Sequence
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Brain Chemistry
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Caffeine / pharmacology
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Calcium / metabolism
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Calcium Channels / genetics
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Calcium Channels / metabolism*
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Cell Division / drug effects
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Cloning, Molecular
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DNA, Complementary / analysis
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Gene Expression
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Humans
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Molecular Sequence Data
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Muscle Proteins / genetics
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Muscle Proteins / metabolism*
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RNA, Messenger / analysis
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Ryanodine / pharmacology
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Ryanodine Receptor Calcium Release Channel
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Sequence Alignment
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Sequence Analysis, DNA
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Sequence Homology, Amino Acid
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T-Lymphocytes / cytology*
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T-Lymphocytes / drug effects
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Tacrolimus / pharmacology
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Tumor Cells, Cultured
Substances
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Calcium Channels
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DNA, Complementary
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Muscle Proteins
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RNA, Messenger
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Ryanodine Receptor Calcium Release Channel
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Ryanodine
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Caffeine
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Calcium
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Tacrolimus