Involvement of the brain type of ryanodine receptor in T-cell proliferation

FEBS Lett. 1994 Sep 26;352(2):206-10. doi: 10.1016/0014-5793(94)00955-4.

Abstract

Cloning and sequence analysis of cDNA showed that the brain type of ryanodine receptor (RYR) is expressed in human Jurkat T-lymphocyte cells. Fura-2 measurements revealed that the RYR in T-cells functions as a ryanodine-sensitive, caffeine-insensitive Ca2+ release channel. Furthermore, ryanodine stimulated proliferation and altered the growth pattern of cultured human T-cells when added together with FK506.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Brain Chemistry
  • Caffeine / pharmacology
  • Calcium / metabolism
  • Calcium Channels / genetics
  • Calcium Channels / metabolism*
  • Cell Division / drug effects
  • Cloning, Molecular
  • DNA, Complementary / analysis
  • Gene Expression
  • Humans
  • Molecular Sequence Data
  • Muscle Proteins / genetics
  • Muscle Proteins / metabolism*
  • RNA, Messenger / analysis
  • Ryanodine / pharmacology
  • Ryanodine Receptor Calcium Release Channel
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid
  • T-Lymphocytes / cytology*
  • T-Lymphocytes / drug effects
  • Tacrolimus / pharmacology
  • Tumor Cells, Cultured

Substances

  • Calcium Channels
  • DNA, Complementary
  • Muscle Proteins
  • RNA, Messenger
  • Ryanodine Receptor Calcium Release Channel
  • Ryanodine
  • Caffeine
  • Calcium
  • Tacrolimus