Evolution and controversies in the management of low-stage nonseminomatous germ-cell tumors of the testis

World J Urol. 1994;12(3):113-9. doi: 10.1007/BF00192265.

Abstract

The results of changing treatment modalities in 690 consecutive patients with low stages nonseminomatous germ-cell tumors (NSGCT) of the testis were analyzed. Overall, 120 patients (17.4%) suffered relapses, and 25 (3.6%) died of cancer after a follow-up period ranging from 2 to 20 years. The indications for primary (nerve-sparing) retroperitoneal lymph-node dissection (RPLND) were gradually restricted from clinical stages I, IIA, and IIB to stages I and IIA with normal postorchiectomy markers only, but we recognize that the management of clinical stage I NSGCT of the testis remains controversial. All other patients may be treated with primary chemotherapy followed by nerve-sparing RPLND for any residual mass. Adjuvant chemotherapy is mandatory in pathological stage IIC disease, but this pathological category will disappear with adoption of the restrictions for primary nerve-sparing RPLND, and two courses of adjuvant chemotherapy are adequate treatment for patients with pathological stages IIA and IIB disease, who cannot be carefully followed.

Publication types

  • Clinical Trial

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Bleomycin / administration & dosage
  • Chemotherapy, Adjuvant
  • Cisplatin / administration & dosage
  • Combined Modality Therapy
  • Follow-Up Studies
  • Germinoma / diagnosis
  • Germinoma / mortality
  • Germinoma / secondary
  • Germinoma / therapy*
  • Humans
  • Lymph Node Excision*
  • Lymphatic Metastasis
  • Lymphography
  • Male
  • Neoplasm Recurrence, Local / mortality
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Recurrence, Local / therapy*
  • Neoplasm Staging
  • Orchiectomy*
  • Remission Induction
  • Retroperitoneal Neoplasms / diagnosis
  • Retroperitoneal Neoplasms / mortality
  • Retroperitoneal Neoplasms / secondary
  • Retroperitoneal Neoplasms / therapy*
  • Survival Rate
  • Testicular Neoplasms / diagnostic imaging
  • Testicular Neoplasms / mortality
  • Testicular Neoplasms / pathology
  • Testicular Neoplasms / therapy*
  • Time Factors
  • Tomography, X-Ray Computed
  • Urography
  • Vinblastine / administration & dosage

Substances

  • Bleomycin
  • Vinblastine
  • Cisplatin

Supplementary concepts

  • PVB protocol