The insulin-like growth factor I receptor gene is the target for the 15q26 amplicon in breast cancer

Genes Chromosomes Cancer. 1994 Sep;11(1):63-5. doi: 10.1002/gcc.2870110110.

Abstract

We report the amplification and overexpression of the IGFIR (insulin-like growth factor I receptor) gene in primary breast cancers with an amplification of band 15q26. The involvement of IGFIR, which may vary in frequency from 2-3% in unselected tumor series to more than 10% in breast cancers with hsr, may represent an important event in tumor progression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blotting, Northern
  • Blotting, Southern
  • Breast Neoplasms / genetics*
  • Carboxylic Ester Hydrolases / biosynthesis
  • Carboxylic Ester Hydrolases / genetics
  • Chromosomes, Human, Pair 15*
  • DNA, Neoplasm / genetics
  • Female
  • Gene Amplification*
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Neoplasm Proteins / biosynthesis
  • Neoplasm Proteins / genetics*
  • Protein-Tyrosine Kinases*
  • Proto-Oncogene Proteins c-fes
  • Proto-Oncogene Proteins*
  • RNA, Neoplasm / genetics
  • Receptor, IGF Type 1 / biosynthesis
  • Receptor, IGF Type 1 / genetics*

Substances

  • DNA, Neoplasm
  • Neoplasm Proteins
  • Proto-Oncogene Proteins
  • RNA, Neoplasm
  • Protein-Tyrosine Kinases
  • Receptor, IGF Type 1
  • FES protein, human
  • Proto-Oncogene Proteins c-fes
  • Carboxylic Ester Hydrolases