Abstract
We report the amplification and overexpression of the IGFIR (insulin-like growth factor I receptor) gene in primary breast cancers with an amplification of band 15q26. The involvement of IGFIR, which may vary in frequency from 2-3% in unselected tumor series to more than 10% in breast cancers with hsr, may represent an important event in tumor progression.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Blotting, Northern
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Blotting, Southern
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Breast Neoplasms / genetics*
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Carboxylic Ester Hydrolases / biosynthesis
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Carboxylic Ester Hydrolases / genetics
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Chromosomes, Human, Pair 15*
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DNA, Neoplasm / genetics
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Female
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Gene Amplification*
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Gene Expression Regulation, Neoplastic
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Humans
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Neoplasm Proteins / biosynthesis
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Neoplasm Proteins / genetics*
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Protein-Tyrosine Kinases*
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Proto-Oncogene Proteins c-fes
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Proto-Oncogene Proteins*
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RNA, Neoplasm / genetics
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Receptor, IGF Type 1 / biosynthesis
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Receptor, IGF Type 1 / genetics*
Substances
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DNA, Neoplasm
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Neoplasm Proteins
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Proto-Oncogene Proteins
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RNA, Neoplasm
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Protein-Tyrosine Kinases
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Receptor, IGF Type 1
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FES protein, human
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Proto-Oncogene Proteins c-fes
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Carboxylic Ester Hydrolases