Abstract
Adhesion-independent growth is a neoplastic phenotype that is inducible in Rat 1a fibroblasts by enforced MYC expression. The c-Myc protein has been well characterized as a transcription factor, yet the molecular basis of c-Myc-induced neoplastic transformation has remained elusive. In this report, we demonstrate a link between ectopic MYC expression, deregulated cyclin A levels, and adhesion-independent growth.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cell Adhesion / physiology*
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Cell Transformation, Neoplastic*
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Cells, Cultured
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Cyclins / genetics
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Cyclins / metabolism*
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Fibroblasts
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Gene Expression Regulation
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Humans
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Proto-Oncogene Proteins c-myc / genetics
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Proto-Oncogene Proteins c-myc / metabolism*
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Rats
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Recombinant Proteins / metabolism
Substances
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Cyclins
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Proto-Oncogene Proteins c-myc
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Recombinant Proteins