A monoclonal antibody which blocks infection with feline immunodeficiency virus identifies a possible non-CD4 receptor

M J Hosie; B J Willett; T H Dunsford; O Jarrett; J C Neil

doi:10.1128/JVI.67.3.1667-1671.1993

A monoclonal antibody which blocks infection with feline immunodeficiency virus identifies a possible non-CD4 receptor

J Virol. 1993 Mar;67(3):1667-71. doi: 10.1128/JVI.67.3.1667-1671.1993.

Authors

M J Hosie¹, B J Willett, T H Dunsford, O Jarrett, J C Neil

Affiliation

¹ Department of Veterinary Pathology, University of Glasgow Veterinary School, Bearsden, Scotland.

Abstract

Monoclonal antibody vpg15 detects a 24-kDa cell surface protein on feline cells permissive for infection with feline immunodeficiency virus (FIV). The antibody blocks infection of FIV-susceptible cells, and expression of the vpg15 marker is decreased in FIV-infected cells in vitro. These results suggest that the antibody may recognize an FIV receptor distinct from CD4.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies, Monoclonal / immunology*
CD4 Antigens / immunology*
Cells, Cultured
Epitopes / immunology
Immunodeficiency Virus, Feline / growth & development*
Lentivirus Infections / immunology*
Receptors, Virus / immunology*

Substances

Antibodies, Monoclonal
CD4 Antigens
Epitopes
Receptors, Virus