Expression of granulocyte colony-stimulating factor receptor on CD10-positive human B-cell precursors

Br J Haematol. 1995 Mar;89(3):623-6. doi: 10.1111/j.1365-2141.1995.tb08373.x.

Abstract

We examined the expression of CD10 and G-CSF receptor (G-CSFR) on the lymphoid population of mononuclear cells obtained from bone marrow (BM) using two-colour analysis. In the BM of children with ALL in remission, the CD10+ population was significantly increased (20.6 +/- 5.1% compared with that of controls (2.5 +/- 0.5%). More than half (61.3 +/- 2.9%) of the CD10+ cells co-expressed G-CSFR, but not CD13. These results indicate G-CSFR+ B-cell precursors are markedly increased in BM of ALL in remission, suggesting the probable involvement of G-CSF in the human early B-cell ontogeny.

MeSH terms

  • Adolescent
  • Antigens, Neoplasm / analysis
  • B-Lymphocytes / immunology*
  • Bone Marrow / immunology
  • Child
  • Child, Preschool
  • Female
  • Fluorescent Antibody Technique
  • Hematopoietic Stem Cells / immunology*
  • Humans
  • Male
  • Neprilysin / analysis*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology*
  • Receptors, Granulocyte Colony-Stimulating Factor / analysis*
  • Remission Induction

Substances

  • Antigens, Neoplasm
  • Receptors, Granulocyte Colony-Stimulating Factor
  • Neprilysin