Antithrombotic therapy is a mainstay in the treatment of patients with thromboembolic diseases of the arterial and venous circulatory systems. Continued work and investigation has provided much-needed information directly applicable to meeting high standards of patient care. The American College of Chest Physicians Consensus Conference on Antithrombotic Therapy has been instrumental in developing guidelines. This article is a synopsis of the proposed guidelines, including recent updates and information that will likely influence future recommendations.