Physical linkage of the gene cluster containing the LCAT gene to the DNA marker D16S124 at human chromosome region 16q22.1

E Frengen; G Brede; F Larsen; G Skretting; H Prydz

doi:10.1159/000133912

Physical linkage of the gene cluster containing the LCAT gene to the DNA marker D16S124 at human chromosome region 16q22.1

Cytogenet Cell Genet. 1995;68(3-4):194-6. doi: 10.1159/000133912.

Authors

E Frengen¹, G Brede, F Larsen, G Skretting, H Prydz

Affiliation

¹ Biotechnology Centre of Oslo, University of Oslo, Norway.

PMID: 7842735
DOI: 10.1159/000133912

Abstract

Pulsed-field gel electrophoresis has been used to construct a long-range restriction map spanning more than 900 kb in the q22.1 region of human chromosome 16. The gene cluster containing the lecithin:cholesterol acyl transferase (LCAT) gene is located less than 480 kb from the anonymous DNA marker D16S124 in this map. The results suggest three putative CpG islands within 125 kb, in addition to the island previously shown to be located within the gene cluster. This implies a clustering of both genes and CpG islands in this chromosomal region.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Mapping*
Chromosomes, Human, Pair 16*
Genetic Linkage*
Genetic Markers
Humans
Multigene Family / genetics*
Phosphatidylcholine-Sterol O-Acyltransferase / genetics*

Substances

Genetic Markers
Phosphatidylcholine-Sterol O-Acyltransferase