A signaling pathway governing early thymocyte maturation

Immunol Today. 1995 Feb;16(2):99-105. doi: 10.1016/0167-5699(95)80096-4.

Abstract

Recent evidence supports the view that p56lck, a non-receptor protein tyrosine kinase, serves as the signaling element that 'senses' synthesis of a functional T-cell receptor beta chain, thereby promoting thymocyte maturation. Here, Steven Anderson and Roger Perlmutter review current data, and outline the features of this developmental program.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / immunology*
  • Clonal Deletion / immunology
  • Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
  • Protein-Tyrosine Kinases / immunology*
  • Receptors, Antigen, T-Cell, alpha-beta / immunology
  • Signal Transduction / immunology
  • Thymus Gland / cytology*

Substances

  • Receptors, Antigen, T-Cell, alpha-beta
  • Protein-Tyrosine Kinases
  • Lymphocyte Specific Protein Tyrosine Kinase p56(lck)