Abstract
Recent evidence supports the view that p56lck, a non-receptor protein tyrosine kinase, serves as the signaling element that 'senses' synthesis of a functional T-cell receptor beta chain, thereby promoting thymocyte maturation. Here, Steven Anderson and Roger Perlmutter review current data, and outline the features of this developmental program.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cell Differentiation / immunology*
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Clonal Deletion / immunology
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Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
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Protein-Tyrosine Kinases / immunology*
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Receptors, Antigen, T-Cell, alpha-beta / immunology
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Signal Transduction / immunology
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Thymus Gland / cytology*
Substances
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Receptors, Antigen, T-Cell, alpha-beta
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Protein-Tyrosine Kinases
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Lymphocyte Specific Protein Tyrosine Kinase p56(lck)