Dose-response and risk assessment considerations for receptor-mediated effects: case study with a TCDD hepatic tumor promotion model

Prog Clin Biol Res. 1994:387:155-71.

Authors

C H Sewall¹, G W Lucier

Affiliation

¹ Laboratory of Biochemical Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.

PMID: 7972245

No abstract available

Publication types

Review

MeSH terms

Animals
Cytochrome P-450 CYP1A2
Cytochrome P-450 Enzyme System / biosynthesis
Cytochrome P-450 Enzyme System / genetics
Dose-Response Relationship, Drug
Enzyme Induction / drug effects
ErbB Receptors / biosynthesis
ErbB Receptors / genetics
Female
Glucuronosyltransferase / biosynthesis
Glucuronosyltransferase / genetics
Liver Neoplasms, Experimental / chemically induced*
Models, Biological
Oxidoreductases / biosynthesis
Oxidoreductases / genetics
Polychlorinated Dibenzodioxins / toxicity*
Rats
Receptors, Aryl Hydrocarbon / drug effects
Receptors, Aryl Hydrocarbon / physiology*
Risk Assessment
Signal Transduction
Thyrotropin / metabolism

Substances

Polychlorinated Dibenzodioxins
Receptors, Aryl Hydrocarbon
Thyrotropin
Cytochrome P-450 Enzyme System
Oxidoreductases
Cytochrome P-450 CYP1A2
Glucuronosyltransferase
ErbB Receptors