Flecainide-induced JT prolongation, T wave inversion and ventricular tachycardia during treatment for symptomatic atrial fibrillation

Int J Cardiol. 1994 May;44(3):285-7. doi: 10.1016/0167-5273(94)90293-3.

Abstract

Two hours after taking 100 mg of flecainide, a patient developed gastrointestinal complaints, dizziness and shortness of breath. The ECG demonstrated novel prolonged JT interval with negative T wave in the precordial leads. During admission, several attacks of non-sustained ventricular tachycardia occurred. The plasma drug concentration was 814 mg/l. Although the tachycardia was non-sustained, cardiovascular collapse developed. Serum electrolytes were normal and myocardial infarction was excluded. The patient is now free of symptoms without medications.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Atrial Fibrillation / drug therapy
  • Atrial Fibrillation / therapy*
  • Electric Countershock
  • Electrocardiography
  • Female
  • Flecainide / adverse effects*
  • Flecainide / therapeutic use
  • Heart Conduction System / drug effects*
  • Humans
  • Tachycardia, Ventricular / chemically induced*

Substances

  • Flecainide