Abstract
We describe three patients with primary myelodysplastic syndrome and immunological manifestations. One had painful cutaneous plaques, arthritis and peripheral neuropathy, another showed cutaneous vasculitis, and a third had Sweet's syndrome. All patients responded dramatically to steroids. Before treatment the patient with Sweet's syndrome had high serum levels of interleukin 6 (IL-6), which were reduced to zero after treatment with steroids. Myelodysplastic syndrome should be considered when evaluating patients with immunological or rheumatic manifestations associated with one or more cytopenias.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Aged
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Arthritis / diagnosis
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Arthritis / immunology
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Arthritis / pathology
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Diagnosis, Differential
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Female
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Humans
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Male
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Middle Aged
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Myelodysplastic Syndromes / diagnosis
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Myelodysplastic Syndromes / immunology*
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Myelodysplastic Syndromes / pathology
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Peripheral Nervous System Diseases / diagnosis
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Peripheral Nervous System Diseases / immunology
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Peripheral Nervous System Diseases / pathology
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Skin / pathology
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Sweet Syndrome / diagnosis
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Sweet Syndrome / immunology
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Sweet Syndrome / pathology
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Vasculitis / diagnosis
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Vasculitis / immunology
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Vasculitis / pathology