Abstract
To investigate the toxicity of beta-amyloid protein which consisted of senile plaques of Alzheimer's disease (AD), this was infused into cerebral ventricle for 14 days by using mini-osmotic pump. The performance of the water maze task in beta-amyloid protein-treated rats was impaired. Choline acetyltransferase activity significantly decreased in the frontal cortex and hippocampus. These results suggest that the deposition of beta-amyloid protein in the brain is related to the impairment of learning and cholinergic neuronal degeneration, and that beta-amyloid protein-treated rats could be used as an animal model for AD.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alzheimer Disease / chemically induced*
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Alzheimer Disease / pathology
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Alzheimer Disease / psychology
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Amyloid beta-Peptides / administration & dosage
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Amyloid beta-Peptides / toxicity*
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Animals
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Brain / pathology
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Choline O-Acetyltransferase / immunology
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Choline O-Acetyltransferase / metabolism
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Disease Models, Animal
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Immunohistochemistry
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Injections, Intraventricular
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Male
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Memory Disorders / chemically induced
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Memory Disorders / psychology
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Neurons / physiology
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Parasympathetic Nervous System / cytology
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Parasympathetic Nervous System / physiopathology
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Rats
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Rats, Wistar
Substances
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Amyloid beta-Peptides
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Choline O-Acetyltransferase