beta-Amyloid protein-induced Alzheimer's disease animal model

Neurosci Lett. 1994 Mar 28;170(1):63-6. doi: 10.1016/0304-3940(94)90239-9.

Abstract

To investigate the toxicity of beta-amyloid protein which consisted of senile plaques of Alzheimer's disease (AD), this was infused into cerebral ventricle for 14 days by using mini-osmotic pump. The performance of the water maze task in beta-amyloid protein-treated rats was impaired. Choline acetyltransferase activity significantly decreased in the frontal cortex and hippocampus. These results suggest that the deposition of beta-amyloid protein in the brain is related to the impairment of learning and cholinergic neuronal degeneration, and that beta-amyloid protein-treated rats could be used as an animal model for AD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / chemically induced*
  • Alzheimer Disease / pathology
  • Alzheimer Disease / psychology
  • Amyloid beta-Peptides / administration & dosage
  • Amyloid beta-Peptides / toxicity*
  • Animals
  • Brain / pathology
  • Choline O-Acetyltransferase / immunology
  • Choline O-Acetyltransferase / metabolism
  • Disease Models, Animal
  • Immunohistochemistry
  • Injections, Intraventricular
  • Male
  • Memory Disorders / chemically induced
  • Memory Disorders / psychology
  • Neurons / physiology
  • Parasympathetic Nervous System / cytology
  • Parasympathetic Nervous System / physiopathology
  • Rats
  • Rats, Wistar

Substances

  • Amyloid beta-Peptides
  • Choline O-Acetyltransferase